Most travelers take I-80. That is fine with me. Taking Highway 50 (the loneliest road in the US) is one of the most wild and glorious routes a person can travel. I prefer to keep it to myself. Okay, go ahead---travel it some day.
An example of the water wars in the west:
There are exactly four towns across the 400 mile route: Ely, Eureka, Austin and Fallon. This is Eureka.
And this is what the views are like. There is a place along the route where you can admire 10,000 year old pictographs!!